| Week | Date | Opponent | Location |
|---|---|---|---|
| 1 | 8/12 | New York Jets NYJ | Bank of America Stadium |
| 2 | 8/18 | @ New York Giants NYG | MetLife Stadium |
| 3 | 8/25 | Detroit Lions DET | Bank of America Stadium |
| 4 | 9/10 | @ Atlanta Falcons ATL | Mercedes-Benz Stadium |
| 5 | 9/18 | New Orleans Saints NO | Bank of America Stadium |
| 6 | 9/24 | @ Seattle Seahawks SEA | Lumen Field |
| 7 | 10/1 | Minnesota Vikings MIN | Bank of America Stadium |
| 8 | 10/8 | @ Detroit Lions DET | Ford Field |
| 9 | 10/15 | @ Miami Dolphins MIA | Hard Rock Stadium |
| 10 | Bye Week | N/A | |
| 11 | 10/29 | Houston Texans HOU | Bank of America Stadium |
| 12 | 11/5 | Indianapolis Colts IND | Bank of America Stadium |
| 13 | 11/9 | @ Chicago Bears CHI | Soldier Field |
| 14 | 11/19 | Dallas Cowboys DAL | Bank of America Stadium |
| 15 | 11/26 | @ Tennessee Titans TEN | Nissan Stadium |
| 16 | 12/3 | @ Tampa Bay Buccaneers TB | Raymond James Stadium |
| 17 | 12/10 | @ New Orleans Saints NO | Caesars Superdome |
| 18 | TBA | Atlanta Falcons ATL | Bank of America Stadium |
| 19 | 12/24 | Green Bay Packers GB | Bank of America Stadium |
| 20 | 12/31 | @ Jacksonville Jaguars JAX | TIAA Bank Field |
| 21 | TBA | Tampa Bay Buccaneers TB | Bank of America Stadium |
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