| Week | Date | Opponent | Location |
|---|---|---|---|
| 1 | TBA | @ Minnesota Vikings MIN | US Bank Stadium |
| 2 | TBA | Carolina Panthers CAR | NRG Stadium |
| 3 | TBA | @ Detroit Lions DET | Ford Field |
| 4 | 9/7 | @ Los Angeles Rams LAR | SoFi Stadium |
| 5 | 9/15 | Tampa Bay Buccaneers TB | NRG Stadium |
| 6 | 9/21 | @ Jacksonville Jaguars JAX | TIAA Bank Field |
| 7 | 9/28 | Tennessee Titans TEN | NRG Stadium |
| 8 | 10/5 | @ Baltimore Ravens BAL | M & T Bank Stadium |
| 9 | TBA | Bye Week | N/A |
| 10 | 10/20 | @ Seattle Seahawks SEA | Lumen Field |
| 11 | 10/26 | San Francisco 49ers SF | NRG Stadium |
| 12 | 11/2 | Denver Broncos DEN | NRG Stadium |
| 13 | 11/9 | Jacksonville Jaguars JAX | NRG Stadium |
| 14 | 11/16 | @ Tennessee Titans TEN | Nissan Stadium |
| 15 | 11/20 | Buffalo Bills BUF | NRG Stadium |
| 16 | 11/30 | @ Indianapolis Colts IND | Lucas Oil Stadium |
| 17 | 12/7 | @ Kansas City Chiefs KC | GEHA Field at Arrowhead Stadium |
| 18 | 12/14 | Arizona Cardinals ARZ | NRG Stadium |
| 19 | 12/21 | Las Vegas Raiders LVR | NRG Stadium |
| 20 | TBA | @ Los Angeles Chargers LAC | SoFi Stadium |
| 21 | TBA | Indianapolis Colts IND | NRG Stadium |
| 22 | TBA | TBA | NRG Stadium |
| 23 | TBA | TBA | NRG Stadium |
| 24 | TBA | TBA | NRG Stadium |
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