| Week | Date | Opponent | Location |
|---|---|---|---|
| 1 | 8/13 | Los Angeles Chargers LAC | NRG Stadium |
| 2 | 8/20 | Las Vegas Raiders LVR | NRG Stadium |
| 3 | 8/28 | @ Carolina Panthers CAR | Bank of America Stadium |
| 4 | 9/13 | Buffalo Bills BUF | NRG Stadium |
| 5 | 9/20 | Cincinnati Bengals CIN | NRG Stadium |
| 6 | 9/27 | @ Indianapolis Colts IND | Lucas Oil Stadium |
| 7 | 10/4 | Dallas Cowboys DAL | NRG Stadium |
| 8 | 10/11 | @ Tennessee Titans TEN | Nissan Stadium |
| 9 | 10/18 | @ Jacksonville Jaguars JAX | Wembley Stadium |
| 10 | 10/25 | New York Giants NYG | NRG Stadium |
| 11 | Bye Week | N/A | |
| 12 | 11/8 | @ Los Angeles Chargers LAC | SoFi Stadium |
| 13 | 11/15 | @ Cleveland Browns CLE | Huntington Bank Field |
| 14 | 11/19 | Indianapolis Colts IND | NRG Stadium |
| 15 | 11/29 | Baltimore Ravens BAL | NRG Stadium |
| 16 | 12/6 | @ Pittsburgh Steelers PIT | Acrisure Stadium |
| 17 | 12/13 | @ Washington Commanders WAS | Northwest Stadium |
| 18 | 12/20 | Jacksonville Jaguars JAX | NRG Stadium |
| 19 | 12/24 | @ Philadelphia Eagles PHI | Lincoln Financial Field |
| 20 | 1/4 | @ Green Bay Packers GB | Lambeau Field |
| 21 | TBA | Tennessee Titans TEN | NRG Stadium |
| 22 | TBA | TBA | NRG Stadium |
| 23 | TBA | TBA | NRG Stadium |
| 24 | TBA | TBA | NRG Stadium |
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