| Week | Date | Opponent | Location |
|---|---|---|---|
| P1 | TBA | New Orleans Saints NO | NRG Stadium |
| P2 | TBA | @ Los Angeles Rams LAR | Sofi Stadium |
| P3 | 8/25 | San Francisco 49ers SF | NRG Stadium |
| 1 | 9/11 | Indianapolis Colts IND | NRG Stadium |
| 2 | 9/18 | @ Denver Broncos DEN | Empower Field at Mile High |
| 3 | 9/25 | @ Chicago Bears CHI | Soldier Field |
| 4 | 10/2 | Los Angeles Chargers LAC | NRG Stadium |
| 5 | 10/9 | @ Jacksonville Jaguars JAX | TIAA Bank Field |
| 6 | 10/16 | Bye Week | N/A |
| 7 | 10/23 | @ Las Vegas Raiders LVR | Allegiant Stadium |
| 8 | 10/30 | Tennessee Titans TEN | NRG Stadium |
| 9 | 11/3 | Philadelphia Eagles PHI | NRG Stadium |
| 10 | 11/13 | @ New York Giants NYG | Metlife Stadium |
| 11 | 11/20 | Washington Commanders WAS | NRG Stadium |
| 12 | 11/27 | @ Miami Dolphins MIA | Hard Rock Stadium |
| 13 | 12/4 | Cleveland Browns CLE | NRG Stadium |
| 14 | 12/11 | @ Dallas Cowboys DAL | AT&T Stadium |
| 15 | 12/18 | Kansas City Chiefs KC | NRG Stadium |
| 16 | 12/24 | @ Tennessee Titans TEN | Nissan Stadium |
| 17 | 1/1 | Jacksonville Jaguars JAX | NRG Stadium |
| 18 | TBA | @ Indianapolis Colts IND | Lucas Oil Stadium |
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