| Week | Date | Opponent | Location |
|---|---|---|---|
| 1 | 8/9 | New York Giants NYG | Highmark Stadium |
| 2 | 8/17 | @ Chicago Bears CHI | Soldier Field |
| 3 | 8/23 | @ Tampa Bay Buccaneers TB | Raymond James Stadium |
| 4 | 9/7 | Baltimore Ravens BAL | Highmark Stadium |
| 5 | 9/14 | @ New York Jets NYJ | MetLife Stadium |
| 6 | 9/18 | Miami Dolphins MIA | Highmark Stadium |
| 7 | 9/28 | New Orleans Saints NO | Highmark Stadium |
| 8 | 10/5 | New England Patriots NE | Highmark Stadium |
| 9 | 10/13 | @ Atlanta Falcons ATL | Mercedes-Benz Stadium |
| 10 | TBA | Bye Week | N/A |
| 11 | 10/26 | @ Carolina Panthers CAR | Bank of America Stadium |
| 12 | 11/2 | Kansas City Chiefs KC | Highmark Stadium |
| 13 | 11/9 | @ Miami Dolphins MIA | Hard Rock Stadium |
| 14 | 11/16 | Tampa Bay Buccaneers TB | Highmark Stadium |
| 15 | 11/20 | @ Houston Texans HOU | NRG Stadium |
| 16 | 11/30 | @ Pittsburgh Steelers PIT | Acrisure Stadium |
| 17 | 12/7 | Cincinnati Bengals CIN | Highmark Stadium |
| 18 | 12/14 | @ New England Patriots NE | Gillette Stadium |
| 19 | 12/21 | @ Cleveland Browns CLE | Huntington Bank Field |
| 20 | 12/28 | Philadelphia Eagles PHI | Highmark Stadium |
| 21 | TBA | New York Jets NYJ | Highmark Stadium |
| 22 | TBA | TBA | Highmark Stadium |
| 23 | TBA | TBA | Highmark Stadium |
| 24 | TBA | TBA | Highmark Stadium |