| Week | Date | Opponent | Location |
|---|---|---|---|
| 1 | 8/15 | @ San Francisco 49ers SF | Levi's Stadium |
| 2 | 8/23 | Seattle Seahawks SEA | Nissan Stadium |
| 3 | 8/29 | Chicago Bears CHI | Nissan Stadium |
| 4 | 9/13 | New York Jets NYJ | Nissan Stadium |
| 5 | 9/20 | Philadelphia Eagles PHI | Nissan Stadium |
| 6 | 9/27 | @ New York Giants NYG | MetLife Stadium |
| 7 | 10/4 | @ Baltimore Ravens BAL | M & T Bank Stadium |
| 8 | 10/11 | Houston Texans HOU | Nissan Stadium |
| 9 | 10/18 | @ Indianapolis Colts IND | Lucas Oil Stadium |
| 10 | 10/25 | Cleveland Browns CLE | Nissan Stadium |
| 11 | 11/1 | @ Cincinnati Bengals CIN | Paycor Stadium |
| 12 | Bye Week | N/A | |
| 13 | 11/15 | Jacksonville Jaguars JAX | Nissan Stadium |
| 14 | 11/22 | @ Dallas Cowboys DAL | AT&T Stadium |
| 15 | 11/29 | @ Jacksonville Jaguars JAX | EverBank Stadium |
| 16 | 12/6 | Washington Commanders WAS | Nissan Stadium |
| 17 | 12/13 | @ Detroit Lions DET | Ford Field |
| 18 | 12/20 | Indianapolis Colts IND | Nissan Stadium |
| 19 | 12/27 | @ Las Vegas Raiders LVR | Allegiant Stadium |
| 20 | 1/3 | Pittsburgh Steelers PIT | Nissan Stadium |
| 21 | 1/10 | @ Houston Texans HOU | NRG Stadium |
| 22 | TBA | TBA | Nissan Stadium |
| 23 | TBA | TBA | Nissan Stadium |
| 24 | TBA | TBA | Nissan Stadium |
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