| Week | Date | Opponent | Location |
|---|---|---|---|
| 1 | 8/12 | @ Chicago Bears CHI | Soldier Field |
| 2 | 8/19 | @ Minnesota Vikings MIN | US Bank Stadium |
| 3 | 8/25 | New England Patriots NE | Nissan Stadium |
| 4 | 9/10 | @ New Orleans Saints NO | Caesars Superdome |
| 5 | 9/17 | Los Angeles Chargers LAC | Nissan Stadium |
| 6 | 9/24 | @ Cleveland Browns CLE | Cleveland Browns Stadium |
| 7 | 10/1 | Cincinnati Bengals CIN | Nissan Stadium |
| 8 | 10/8 | @ Indianapolis Colts IND | Lucas Oil Stadium |
| 9 | 10/15 | Baltimore Ravens BAL | Tottenham Hotspur Stadium |
| 10 | Bye Week | N/A | |
| 11 | 10/29 | Atlanta Falcons ATL | Nissan Stadium |
| 12 | 11/2 | @ Pittsburgh Steelers PIT | Acrisure Stadium |
| 13 | 11/12 | @ Tampa Bay Buccaneers TB | Raymond James Stadium |
| 14 | 11/19 | @ Jacksonville Jaguars JAX | TIAA Bank Field |
| 15 | 11/26 | Carolina Panthers CAR | Nissan Stadium |
| 16 | 12/3 | Indianapolis Colts IND | Nissan Stadium |
| 17 | 12/11 | @ Miami Dolphins MIA | Hard Rock Stadium |
| 18 | 12/17 | Houston Texans HOU | Nissan Stadium |
| 19 | 12/24 | Seattle Seahawks SEA | Nissan Stadium |
| 20 | 12/31 | @ Houston Texans HOU | NRG Stadium |
| 21 | TBA | Jacksonville Jaguars JAX | Nissan Stadium |
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