| Week | Date | Opponent | Location |
|---|---|---|---|
| 1 | 8/9 | @ Tampa Bay Buccaneers TB | Raymond James Stadium |
| 2 | 8/15 | @ Atlanta Falcons ATL | Mercedes-Benz Stadium |
| 3 | 8/22 | Minnesota Vikings MIN | Nissan Stadium |
| 4 | 9/7 | @ Denver Broncos DEN | Empower Field at Mile High |
| 5 | 9/14 | Los Angeles Rams LAR | Nissan Stadium |
| 6 | 9/21 | Indianapolis Colts IND | Nissan Stadium |
| 7 | 9/28 | @ Houston Texans HOU | NRG Stadium |
| 8 | 10/5 | @ Arizona Cardinals ARZ | State Farm Stadium |
| 9 | 10/12 | @ Las Vegas Raiders LVR | Allegiant Stadium |
| 10 | 10/19 | New England Patriots NE | Nissan Stadium |
| 11 | 10/26 | @ Indianapolis Colts IND | Lucas Oil Stadium |
| 12 | 11/2 | Los Angeles Chargers LAC | Nissan Stadium |
| 13 | TBA | Bye Week | N/A |
| 14 | 11/16 | Houston Texans HOU | Nissan Stadium |
| 15 | 11/23 | Seattle Seahawks SEA | Nissan Stadium |
| 16 | 11/30 | Jacksonville Jaguars JAX | Nissan Stadium |
| 17 | 12/7 | @ Cleveland Browns CLE | Huntington Bank Field |
| 18 | 12/14 | @ San Francisco 49ers SF | Levi's Stadium |
| 19 | 12/21 | Kansas City Chiefs KC | Nissan Stadium |
| 20 | 12/28 | New Orleans Saints NO | Nissan Stadium |
| 21 | TBA | @ Jacksonville Jaguars JAX | TIAA Bank Field |
| 22 | TBA | TBA | Nissan Stadium |
| 23 | TBA | TBA | Nissan Stadium |
| 24 | TBA | TBA | Nissan Stadium |
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